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Abnormalities happen as a result of an accident, most of the time. Its a typo in the DNA that gets carbon copied as the child develops. Most of the time it isn't the parents fault and is one of those things that just happens. Its standard practice to test the parents because the more data the doctors have the better they will understand genetics.
Unless your a soldier, in the military, or live in a country where there was a war recently, you shouldn't have anything to worry about. If this does apply to you, then inform the doctor that you have long term exposure to depleted uranium.
I did a little research and this is the only thing I could find on 22. But its not a mono, but rather refers to a deletion.
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2q11 deletion syndrome (deletion on chromosome 22): About 1 in 4,000 babies is born with deletions in a specific region of chromosome 22 (4). These deletions cause a variety of problems that can include heart defects, cleft lip/palate, immune system abnormalities, characteristic facial features and learning disabilities. Certain combinations of these features are sometimes called DiGeorge or velocardiofacial syndrome. Individuals with this disorder have a 50-percent chance of passing the chromosomal abnormality on to their offspring with each pregnancy (4).
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